SLC45A3

Across TCGA patient cohorts, SLC45A3 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC45A3-associated genes across cancer lineages are MSH2, p62 Lck ligand, and PKC-b-II_pS660. Each is linked with SLC45A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC45A3-to-partner and partner-to-SLC45A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by SLC45A3-low versus SLC45A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC45A3→partner) and Y-score (partner→SLC45A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.293	-2.433	<.001	.018	3	2
UCEC	p62 Lck ligand →	+0.249	+1.502	.037	.030	3	2
UCEC	PKC-b-II_pS660 →	-0.235	-1.906	.021	.015	3	2
UCEC	Bak →	+0.253	+1.847	.006	.008	3	2
UCEC	4E-BP1 →	+0.393	+3.837	<.001	<.001	3	2
UCEC	Cyclin-E2 →	+0.155	+1.916	.012	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

MSH2 by SLC45A3 expression — UCEC

Explore this box plot interactively →