SLC45A1

Across TCGA pan-cancer cohorts, SLC45A1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated SLC45A1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SLC45A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC45A1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

ESCA, THYM, and LIHC are the cancer types where SLC45A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.074	0.703	<.001	48	view →
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LIHC	DFS	Median	All	0.071	0.544	<.001	18	view →
BLCA	OS	Median	II,III,IV	1.000	0.408	.006	18	view →
LUSC	OS	Median	II,III,IV	0.178	0.743	.004	18	view →
READ	OS	Median	II,III,IV	0.187	0.644	.023	9	view →
PRAD	DFS	Median	All	0.422	0.888	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	6	view →
SKCM	DFS	Median	III,IV	0.188	0.652	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

SLC45A1–ESCA (OS)

Open the ESCA breakdown →