SLC45A1

Across TCGA patient cohorts, SLC45A1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC45A1-associated genes across cancer lineages are Cyclin-B1, ASNS, and PKC-a_pS657. Each is linked with SLC45A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC45A1-to-partner and partner-to-SLC45A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SLC45A1-low versus SLC45A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC45A1→partner) and Y-score (partner→SLC45A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.755	+2.807	<.001	.002	3	3
COAD	ASNS →	+0.815	+3.008	<.001	.019	3	3
BLCA	PKC-a_pS657 →	-0.296	-2.321	.045	.035	3	2
UCEC	eEF2 →	+0.343	+2.321	.007	.033	3	2
UCEC	Ku80 →	+0.200	+1.293	.018	.037	3	2
UCEC	Notch1 →	+0.173	+2.009	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Cyclin-B1 by SLC45A1 expression — UCEC

Explore this box plot interactively →