SLC44A5

Across TCGA pan-cancer cohorts, SLC44A5 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated SLC44A5 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SLC44A5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC44A5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, SKCM, and HNSC are the cancer types where SLC44A5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.171	0.625	<.001	30	view →
SKCM	OS	Median	All	0.661	0.798	<.001	21	view →
HNSC	OS	Median	IV	0.156	0.708	.007	18	view →
UCEC	DFS	Median	II,III,IV	0.879	0.303	.016	18	view →
LUSC	OS	Median	IV	0.001	0.673	.014	12	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
BRCA	OS	Median	All	0.746	0.925	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SLC44A5–COAD (OS)

Open the COAD breakdown →