Across TCGA pan-cancer cohorts, SLC44A4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLC44A4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SLC44A4 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC44A4 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where SLC44A4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC44A4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−3.048	<.001	12	view →
KICH	Female	III,IV	−5.683	<.001	11	view →
COAD	Female	II,III,IV	−1.669	<.001	10	view →
THCA	Male	IV	−2.146	<.001	9	view →
LUSC	Male	II,III,IV	−3.799	<.001	8	view →
BRCA	All	III,IV	+2.785	<.001	6	view →
KIRP	All	III,IV	−2.314	.002	5	view →
READ	All	All	−1.603	<.001	5	view →
STAD	All	All	+2.067	.009	3	view →
LIHC	All	II,III,IV	+0.773	.013	3	view →
PRAD	All	All	+1.041	<.001	2	view →
LUAD	Female	II,III,IV	+0.820	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

Exploration

Same gene, other analysis: SLC44A4 RNA expression & survival · all SLC44A4 data types