Across TCGA pan-cancer cohorts, SLC44A4 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SLC44A4’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SLC44A4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SLC44A4 is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where SLC44A4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC44A4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−2.039	<.001	12	view →
PDAC	Female	II,III,IV	+1.792	<.001	11	view →
LSCC	Female	All	−1.455	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SLC44A4 RNA expression & survival · all SLC44A4 data types