SLC44A3

Across TCGA pan-cancer cohorts, SLC44A3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC44A3 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SLC44A3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC44A3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where SLC44A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.368	1.000	.006	24	view →
UCEC	OS	Median	All	0.969	0.849	.029	16	view →
CCRCC	OS	Tertile	III,IV	0.888	0.698	.027	6	view →
LSCC	OS	Quartile	II,III,IV	0.601	1.000	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC44A3–PDAC (DFS)

Open the PDAC breakdown →