SLC43A3

Across TCGA patient cohorts, SLC43A3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC43A3-associated genes across cancer lineages are MEK1, Shc_pY317, and Smad1. Each is linked with SLC43A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC43A3-to-partner and partner-to-SLC43A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLC43A3-low versus SLC43A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC43A3→partner) and Y-score (partner→SLC43A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.326	+2.000	.048	.032	3	2
UCEC	Shc_pY317 →	-0.257	-3.169	<.001	.019	3	2
UCEC	Smad1 →	+0.183	+2.000	.009	.032	3	2
UCEC	P-Cadherin →	-0.156	-2.999	.016	.035	3	1
UCEC	Src_pY416 →	-0.306	-2.687	.004	.006	3	1
UCEC	VHL →	-1.253	-3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MEK1 by SLC43A3 expression — UCEC

Explore this box plot interactively →