SLC41A3

Across TCGA pan-cancer cohorts, SLC41A3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC41A3 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SLC41A3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SLC41A3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where SLC41A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.408	1.000	.009	24	view →
HNSC	DFS	Quartile	All	1.000	0.768	.001	21	view →
LUAD	OS	Median	II,III,IV	1.000	0.339	<.001	12	view →
PDAC	OS	Tertile	II,III,IV	0.976	0.684	.020	11	view →
LSCC	OS	Quartile	II,III,IV	0.765	1.000	.023	4	view →
CCRCC	DFS	Tertile	II,III,IV	0.702	0.278	.015	3	view →
GBM	DFS	Tertile	All	0.793	0.649	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC41A3–UCEC (OS)

Open the UCEC breakdown →