SLC41A3

Across TCGA patient cohorts, SLC41A3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC41A3-associated genes across cancer lineages are JNK2, AMPK_pT172, and ATM. Each is linked with SLC41A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC41A3-to-partner and partner-to-SLC41A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SLC41A3-low versus SLC41A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC41A3→partner) and Y-score (partner→SLC41A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.223	+2.486	<.001	.009	3	2
UCEC	AMPK_pT172 →	+0.326	+1.906	.018	.015	3	2
UCEC	ATM →	-0.442	-1.874	.003	.002	3	2
UCEC	eIF4E →	+0.165	+2.013	.019	.016	3	1
UCEC	ERK2 →	+0.152	+2.700	.018	.005	3	1
UCEC	GATA6 →	-0.138	-1.906	.008	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

JNK2 by SLC41A3 expression — UCEC

Explore this box plot interactively →