SLC41A3

Across TCGA cell cohorts, SLC41A3 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible SLC41A3-associated genes across cancer lineages are RXFP2, CSN2, and OR13C9. Each is linked with SLC41A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC41A3-to-partner and partner-to-SLC41A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RXFP2 grouped by SLC41A3-low versus SLC41A3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC41A3→partner) and Y-score (partner→SLC41A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RXFP2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CSN2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR13C9 →	+0.090	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	KIF2B →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	VSIG4 →	+0.036	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	HTR5A →	+0.006	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

RXFP2 by SLC41A3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →