SLC41A2

Across TCGA patient cohorts, SLC41A2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC41A2-associated genes across cancer lineages are Bak, c-Met_pY1235, and Cyclin-B1. Each is linked with SLC41A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC41A2-to-partner and partner-to-SLC41A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by SLC41A2-low versus SLC41A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC41A2→partner) and Y-score (partner→SLC41A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.252	+3.459	.007	.005	3	2
UCEC	c-Met_pY1235 →	+0.056	+1.415	.044	.046	3	2
UCEC	Cyclin-B1 →	+0.775	+3.807	<.001	<.001	3	2
UCEC	Cyclin-E2 →	+0.170	+2.710	.007	.003	3	2
UCEC	EGFR_pY1068 →	-0.224	-1.765	.017	.014	3	1
UCEC	A-Raf_pS299 →	-0.114	-3.321	.011	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Bak by SLC41A2 expression — UCEC

Explore this box plot interactively →