SLC41A2

Across TCGA cell cohorts, SLC41A2 mutation is significantly associated with the drug of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC41A2-associated genes across cancer lineages are TL-2-105, GSK429286A, and Quizartinib. Each is linked with SLC41A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC41A2-to-partner and partner-to-SLC41A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TL-2-105 grouped by SLC41A2-low versus SLC41A2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC41A2→partner) and Y-score (partner→SLC41A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TL-2-105 →	+0.438	+2.652	.026	.045	3	1
LARGE_INTESTINE	GSK429286A →	+0.344	+2.652	.027	.045	3	1
LARGE_INTESTINE	Quizartinib →	+0.382	+2.652	.017	.045	3	1
LARGE_INTESTINE	WYE-125132 →	+0.636	+2.652	.012	.045	3	1
LARGE_INTESTINE	Torin 2 →	+0.608	+2.655	.023	.044	3	1
LARGE_INTESTINE	GSK690693 →	+0.742	+2.652	.002	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TL-2-105 by SLC41A2 expression — LARGE_INTESTINE

Explore this box plot interactively →