SLC41A1

Across TCGA patient cohorts, SLC41A1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC41A1-associated genes across cancer lineages are PDCD4, EGFR_pY1068, and Rad50. Each is linked with SLC41A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC41A1-to-partner and partner-to-SLC41A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLC41A1-low versus SLC41A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC41A1→partner) and Y-score (partner→SLC41A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.612	-2.222	.002	.011	3	3
UCEC	EGFR_pY1068 →	-0.238	-2.222	.025	.011	3	2
UCEC	Rad50 →	-0.217	-1.700	.035	.044	3	2
UCEC	ATM →	-0.692	-3.446	<.001	.005	3	2
UCEC	c-Kit →	-0.255	-2.222	.010	.011	3	2
COAD	4E-BP1_pT70 →	+0.152	+2.815	.020	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PDCD4 by SLC41A1 expression — UCEC

Explore this box plot interactively →