SLC40A1

Across TCGA patient cohorts, SLC40A1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC40A1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and JNK2. Each is linked with SLC40A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC40A1-to-partner and partner-to-SLC40A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC40A1-low versus SLC40A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC40A1→partner) and Y-score (partner→SLC40A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.828	+3.720	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.298	+3.321	.006	.009	3	2
UCEC	JNK2 →	+0.203	+2.179	.010	.034	3	1
UCEC	Ku80 →	+0.261	+2.428	.005	.002	3	1
UCEC	MEK1 →	+0.326	+1.906	.026	.016	3	1
UCEC	p62 Lck ligand →	+0.307	+2.415	.019	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-7-cleavedD198 by SLC40A1 expression — UCEC

Explore this box plot interactively →