SLC40A1

Across TCGA cell cohorts, SLC40A1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SLC40A1-associated genes across cancer lineages are OR56A5, HTR2A, and RHBG. Each is linked with SLC40A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC40A1-to-partner and partner-to-SLC40A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by SLC40A1-low versus SLC40A1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC40A1→partner) and Y-score (partner→SLC40A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	2
BLOOD_Lymphoma	HTR2A →	+0.039	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	RHBG →	+0.023	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	OR10H1 →	+0.011	+4.321	.001	.002	3	1
BLOOD_Lymphoma	OR52B2 →	+0.039	+5.129	<.001	<.001	3	1
LARGE_INTESTINE	TMEM95 →	+0.014	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR56A5 by SLC40A1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →