SLC3A1

Across TCGA patient cohorts, SLC3A1 mutation is significantly associated with the RNA expression of many other genes, with 4,968 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC3A1-associated genes across cancer lineages are FANCG, POLDIP3, and MRPS15. Each is linked with SLC3A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC3A1-to-partner and partner-to-SLC3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCG grouped by SLC3A1-low versus SLC3A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC3A1→partner) and Y-score (partner→SLC3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCG →	+0.659	+2.021	<.001	<.001	3	4
UCEC	POLDIP3 →	+0.528	+2.042	<.001	<.001	3	4
UCEC	MRPS15 →	+0.388	+1.737	<.001	.002	3	4
UCEC	ABHD3 →	+0.664	+2.684	<.001	<.001	3	4
UCEC	LRRC57 →	+0.547	+2.321	<.001	<.001	3	3
UCEC	BRI3BP →	+0.653	+2.711	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,968 associations by consensus.

FANCG by SLC3A1 expression — UCEC

Explore this box plot interactively →