SLC3A1

Across TCGA patient cohorts, SLC3A1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC3A1-associated genes across cancer lineages are Cyclin-B1, mTOR_pS2448, and PCNA. Each is linked with SLC3A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC3A1-to-partner and partner-to-SLC3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SLC3A1-low versus SLC3A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC3A1→partner) and Y-score (partner→SLC3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.625	+3.700	.001	.001	3	3
UCEC	mTOR_pS2448 →	-0.164	-3.074	.001	<.001	3	3
UCEC	PCNA →	+0.260	+3.584	<.001	.002	3	3
UCEC	ATM →	-0.548	-2.070	<.001	.001	3	3
STAD	GSK-3_pS9 →	-0.574	-3.000	.003	.036	3	2
UCEC	FoxM1 →	+0.214	+1.736	.017	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Cyclin-B1 by SLC3A1 expression — UCEC

Explore this box plot interactively →