SLC39A6

Across TCGA pan-cancer cohorts, SLC39A6 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SLC39A6 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SLC39A6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC39A6 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, KIRC, and LIHC are the cancer types where SLC39A6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.144	0.705	.004	18	view →
KIRC	OS	Median	All	0.144	0.655	.029	12	view →
LIHC	OS	Median	All	0.156	0.774	.005	9	view →
LUSC	OS	Median	All	0.164	0.762	.018	6	view →
LUAD	OS	Median	III,IV	0.228	0.677	.015	6	view →
UCEC	DFS	Median	All	0.901	0.619	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SLC39A6–CESC (DFS)

Open the CESC breakdown →