SLC39A6

Across TCGA patient cohorts, SLC39A6 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC39A6-associated genes across cancer lineages are INPP4B, JNK_pT183_Y185, and p38-MAPK_pT180_Y182. Each is linked with SLC39A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC39A6-to-partner and partner-to-SLC39A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SLC39A6-low versus SLC39A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A6→partner) and Y-score (partner→SLC39A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.227	-2.115	.047	.016	3	2
UCEC	JNK_pT183_Y185 →	-0.134	-1.700	.024	.042	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.417	-1.807	.008	.025	3	2
UCEC	PDCD4 →	-0.346	-1.362	.037	.037	3	2
UCEC	Rab11 →	-0.107	-1.680	.036	.042	3	2
UCEC	Stathmin →	+0.101	+1.900	.037	.028	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

INPP4B by SLC39A6 expression — UCEC

Explore this box plot interactively →