SLC39A6

Across TCGA cell cohorts, SLC39A6 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC39A6-associated genes across cancer lineages are REG1B, GALP, and ZAN. Each is linked with SLC39A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC39A6-to-partner and partner-to-SLC39A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by SLC39A6-low versus SLC39A6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A6→partner) and Y-score (partner→SLC39A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.588	+2.518	<.001	.006	3	2
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	2
LUNG_NSCLC_LUAD	ZAN →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	LRRC52 →	+1.613	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	SPZ1 →	+0.011	+4.734	.001	.002	3	1
LUNG_NSCLC_LUAD	MBD3L1 →	+0.157	+4.734	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

REG1B by SLC39A6 expression — LARGE_INTESTINE

Explore this box plot interactively →