SLC39A6

Across TCGA cell cohorts, SLC39A6 mutation is significantly associated with the mutation status of many other genes, with 4,118 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC39A6-associated genes across cancer lineages are RGS12, ATP6V0A4, and MET. Each is linked with SLC39A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC39A6-to-partner and partner-to-SLC39A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGS12 grouped by SLC39A6-low versus SLC39A6-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A6→partner) and Y-score (partner→SLC39A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RGS12 →	+4.502	+5.066	.007	.007	1	3
SOFT_TISSUE	ATP6V0A4 →	+4.502	+5.066	.007	.007	1	3
SOFT_TISSUE	MET →	+4.502	+5.066	.007	.007	1	3
SKIN	DIP2C →	+2.655	+4.113	.009	.009	1	3
SKIN	NCAPD3 →	+4.977	+5.638	<.001	<.001	1	3
SKIN	SPEF2 →	+2.807	+4.247	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,118 associations by consensus.

RGS12 by SLC39A6 expression — SOFT_TISSUE

Explore this box plot interactively →