SLC39A5

Across TCGA patient cohorts, SLC39A5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC39A5-associated genes across cancer lineages are eIF4E, MSH2, and MSH6. Each is linked with SLC39A5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC39A5-to-partner and partner-to-SLC39A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SLC39A5-low versus SLC39A5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A5→partner) and Y-score (partner→SLC39A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.280	+3.321	<.001	.009	2	3
UCEC	MSH2 →	-0.300	-1.584	<.001	.036	3	2
UCEC	MSH6 →	-0.363	-2.321	.005	.033	3	2
UCEC	PKC-delta_pS664 →	-0.098	-1.584	.038	.036	3	2
UCEC	ATM →	-0.430	-3.308	.015	.009	3	2
UCEC	ERK2 →	+0.150	+2.999	.046	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by SLC39A5 expression — SKCM

Explore this box plot interactively →