SLC39A5

Across TCGA cell cohorts, SLC39A5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,750 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC39A5-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Regulation of gastrulation, and Mitochondrion-endoplasmic reticulum membrane tethering. Each is linked with SLC39A5 in more than 8 cancer types. Because this analysis shows association rather than direction, both SLC39A5-to-partner and partner-to-SLC39A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by SLC39A5-low versus SLC39A5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A5→partner) and Y-score (partner→SLC39A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.198	+0.198	<.001	.001	3	9
STOMACH	Regulation of gastrulation →	-0.192	-2.390	<.001	.007	3	8
SOFT_TISSUE	Mitochondrion-endoplasmic reticulum membrane tethering →	+0.085	+0.154	.001	.003	3	8
STOMACH	Plasmacytoid dendritic cell activation →	-0.145	-1.689	<.001	.005	3	8
BONE	Microtubule nucleation →	+0.120	+0.243	<.001	.001	3	8
LARGE_INTESTINE	Positive regulation of calcium ion import →	-0.115	-3.226	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,750 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by SLC39A5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →