SLC39A4

Across TCGA patient cohorts, SLC39A4 mutation is significantly associated with the RNA expression of many other genes, with 311 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC39A4-associated genes across cancer lineages are RNU6-741P, PCMTD1P1, and OR4K14. Each is linked with SLC39A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC39A4-to-partner and partner-to-SLC39A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-741P grouped by SLC39A4-low versus SLC39A4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A4→partner) and Y-score (partner→SLC39A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-741P →	+0.189	+4.475	<.001	.005	3	3
HNSC	PCMTD1P1 →	+0.080	+4.526	<.001	.007	3	3
SKCM	OR4K14 →	+0.024	+4.147	<.001	.008	3	2
UCEC	RNA5SP417 →	+0.419	+2.503	.006	.004	3	2
UCEC	RNA5SP421 →	+0.737	+2.188	<.001	.007	3	2
COAD	RNY4P9 →	+0.526	+5.145	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

RNU6-741P by SLC39A4 expression — SKCM

Explore this box plot interactively →