SLC39A4

Across TCGA cell cohorts, SLC39A4 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC39A4-associated genes across cancer lineages are METTL21C, FAM205A, and AVP. Each is linked with SLC39A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC39A4-to-partner and partner-to-SLC39A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL21C grouped by SLC39A4-low versus SLC39A4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A4→partner) and Y-score (partner→SLC39A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	METTL21C →	+0.041	+3.716	.008	.005	3	1
BLOOD_Myeloma	FAM205A →	+0.027	+3.977	<.001	.006	3	1
CNS	AVP →	+0.083	+4.981	<.001	.008	3	1
LUNG_SCLC	ATP6V1G3 →	+0.287	+4.269	.006	.005	3	1
LUNG_SCLC	RBMY1F →	+0.782	+4.643	<.001	.004	3	1
LARGE_INTESTINE	PTH →	+0.033	+3.099	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

METTL21C by SLC39A4 expression — BLOOD_Myeloma

Explore this box plot interactively →