SLC39A3

Across TCGA cell cohorts, SLC39A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,627 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC39A3-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Negative regulation of protein localization to chromatin, and Protein depolymerization. Each is linked with SLC39A3 in more than 14 cancer types. Because this analysis shows association rather than direction, both SLC39A3-to-partner and partner-to-SLC39A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by SLC39A3-low versus SLC39A3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A3→partner) and Y-score (partner→SLC39A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.136	+0.703	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.145	+0.938	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Protein depolymerization →	+0.136	+0.830	<.001	<.001	3	12
OESOPHAGUS	Multi-pass transmembrane protein insertion into ER membrane →	+0.125	+0.667	.001	.009	3	11
PANCREAS	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.157	+0.880	<.001	<.001	3	10
SKIN	Pigment metabolic process involved in pigmentation →	+0.248	+0.771	.002	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,627 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by SLC39A3 expression — LUNG_SCLC

Explore this box plot interactively →