SLC39A14

Across TCGA pan-cancer cohorts, SLC39A14 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC39A14 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC39A14 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SLC39A14 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where SLC39A14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.672	0.981	<.001	34	view →
PDAC	OS	Median	IV	0.381	0.951	.006	9	view →
UCEC	DFS	Quartile	III,IV	1.000	0.409	.040	8	view →
GBM	OS	Tertile	All	0.305	0.538	.033	6	view →
HNSC	OS	Quartile	III,IV	0.819	0.552	.007	5	view →
OV	DFS	Median	All	0.923	0.632	.017	4	view →
LSCC	DFS	Tertile	All	0.456	0.986	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC39A14–CCRCC (OS)

Open the CCRCC breakdown →