SLC39A11

Across TCGA patient cohorts, SLC39A11 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC39A11-associated genes across cancer lineages are Caspase-8, C-Raf, and EGFR_pY1068. Each is linked with SLC39A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC39A11-to-partner and partner-to-SLC39A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by SLC39A11-low versus SLC39A11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A11→partner) and Y-score (partner→SLC39A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.262	-3.295	.017	.009	3	2
UCEC	C-Raf →	+0.210	+2.807	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.272	-2.321	.013	.034	3	1
UCEC	eIF4E →	+0.192	+2.115	.037	.019	3	1
UCEC	eIF4G →	+0.317	+2.999	.019	.035	3	1
UCEC	A-Raf_pS299 →	-0.161	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-8 by SLC39A11 expression — UCEC

Explore this box plot interactively →