SLC39A1

Across TCGA cell cohorts, SLC39A1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC39A1-associated genes across cancer lineages are SLC22A7, TFAP2D, and LCN1. Each is linked with SLC39A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC39A1-to-partner and partner-to-SLC39A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A7 grouped by SLC39A1-low versus SLC39A1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A1→partner) and Y-score (partner→SLC39A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC22A7 →	+0.036	+6.022	<.001	.001	3	1
SKIN	TFAP2D →	+0.154	+5.415	<.001	.004	3	1
BLOOD_Leukemia	LCN1 →	+0.037	+4.922	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	FAM24A →	+0.082	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SLC22A7 by SLC39A1 expression — SKIN

Explore this box plot interactively →