SLC38A8

Across TCGA patient cohorts, SLC38A8 mutation is significantly associated with the RNA expression of many other genes, with 1,194 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC38A8-associated genes across cancer lineages are PSMD6, GHITM, and CRK. Each is linked with SLC38A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A8-to-partner and partner-to-SLC38A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD6 grouped by SLC38A8-low versus SLC38A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A8→partner) and Y-score (partner→SLC38A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD6 →	+0.303	+2.523	.008	.009	3	2
UCEC	GHITM →	+0.483	+1.847	.007	.009	3	2
UCEC	CRK →	+0.341	+1.869	.008	.005	3	2
UCEC	FEN1 →	+0.619	+2.415	.001	.003	3	2
UCEC	AHCYL1 →	+0.484	+2.749	.002	.003	3	2
UCEC	TMEM126A →	+0.384	+2.247	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,194 associations by consensus.

PSMD6 by SLC38A8 expression — UCEC

Explore this box plot interactively →