SLC38A8

Across TCGA patient cohorts, SLC38A8 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC38A8-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with SLC38A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A8-to-partner and partner-to-SLC38A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SLC38A8-low versus SLC38A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A8→partner) and Y-score (partner→SLC38A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.256	+4.087	.003	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.669	+2.341	.006	.019	3	2
UCEC	4E-BP1 →	+0.274	+2.199	.014	.033	3	2
UCEC	Cyclin-B1 →	+0.486	+2.999	.036	.035	3	2
UCEC	ERK2 →	+0.222	+3.321	.005	.009	3	1
UCEC	Fibronectin →	-0.283	-1.807	.038	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by SLC38A8 expression — UCEC

Explore this box plot interactively →