SLC38A8

Across TCGA cell cohorts, SLC38A8 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC38A8-associated genes across cancer lineages are CST5, C20orf173, and CD8B. Each is linked with SLC38A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A8-to-partner and partner-to-SLC38A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST5 grouped by SLC38A8-low versus SLC38A8-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A8→partner) and Y-score (partner→SLC38A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CST5 →	+0.113	+4.981	<.001	.008	3	1
LUNG_NSCLC_LUAD	C20orf173 →	+0.030	+3.977	.004	.005	3	1
LUNG_NSCLC_LUAD	CD8B →	+0.333	+3.874	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR52B4 →	+0.011	+4.078	<.001	.009	3	1
LARGE_INTESTINE	XKR3 →	+0.035	+3.793	.003	.007	3	1
LARGE_INTESTINE	OR10Q1 →	+0.092	+3.920	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

CST5 by SLC38A8 expression — CNS

Explore this box plot interactively →