SLC38A7

Across TCGA patient cohorts, SLC38A7 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC38A7-associated genes across cancer lineages are p21, 14-3-3_beta, and EGFR_pY1068. Each is linked with SLC38A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A7-to-partner and partner-to-SLC38A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by SLC38A7-low versus SLC38A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A7→partner) and Y-score (partner→SLC38A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.141	+1.736	.034	.007	3	2
UCEC	14-3-3_beta →	-0.081	-2.432	.020	.018	3	1
UCEC	EGFR_pY1068 →	-0.239	-1.736	.006	.007	3	1
UCEC	EGFR →	-0.132	-2.000	.017	.030	3	1
UCEC	eIF4E →	+0.151	+2.183	.039	.033	3	1
UCEC	A-Raf_pS299 →	-0.148	-2.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p21 by SLC38A7 expression — UCEC

Explore this box plot interactively →