SLC38A6

Across TCGA patient cohorts, SLC38A6 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC38A6-associated genes across cancer lineages are ER-alpha_pS118, MSH2, and MSH6. Each is linked with SLC38A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A6-to-partner and partner-to-SLC38A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by SLC38A6-low versus SLC38A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A6→partner) and Y-score (partner→SLC38A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	-0.352	-2.584	.035	.011	3	1
UCEC	MSH2 →	-0.452	-3.295	<.001	.009	3	1
UCEC	MSH6 →	-0.546	-3.321	<.001	.009	3	1
UCEC	PDCD4 →	-0.536	-3.160	.014	.019	3	1
UCEC	PR →	-0.231	-2.999	.048	.035	3	1
UCEC	TIGAR →	+0.172	+2.611	.015	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ER-alpha_pS118 by SLC38A6 expression — UCEC

Explore this box plot interactively →