Across TCGA patient cohorts, SLC38A3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC38A3-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with SLC38A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A3-to-partner and partner-to-SLC38A3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A3→partner) and Y-score (partner→SLC38A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.369	+2.459	.010	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.819	+3.584	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.296	-2.700	.002	.006	3	1
UCEC	EGFR →	-0.166	-3.321	.008	.010	3	1
UCEC	eIF4E →	+0.174	+3.013	.035	.018	3	1
UCEC	ERK2 →	+0.206	+2.502	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

SLC38A3 survival (RNA) · tumor vs normal (RNA) · all SLC38A3 data types