SLC37A4

Across TCGA pan-cancer cohorts, SLC37A4 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SLC37A4 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC37A4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SLC37A4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where SLC37A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.879	0.585	.002	54	view →
HNSC	OS	Median	IV	0.933	0.554	.003	14	view →
PDAC	DFS	Median	III,IV	0.582	0.178	.002	12	view →
COAD	DFS	Median	III,IV	0.833	1.000	.045	6	view →
LSCC	DFS	Median	II,III,IV	0.303	1.000	<.001	6	view →
LUAD	DFS	Median	All	0.668	0.914	.021	5	view →
GBM	OS	Quartile	All	0.641	0.944	.016	3	view →
UCEC	DFS	Median	All	1.000	0.942	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SLC37A4–CCRCC (OS)

Open the CCRCC breakdown →