SLC37A4

Across TCGA patient cohorts, SLC37A4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC37A4-associated genes across cancer lineages are Chk2_pT68, EGFR_pY1068, and eIF4E. Each is linked with SLC37A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC37A4-to-partner and partner-to-SLC37A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by SLC37A4-low versus SLC37A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC37A4→partner) and Y-score (partner→SLC37A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.177	-2.312	.029	.034	3	2
UCEC	EGFR_pY1068 →	-0.253	-2.115	.021	.019	3	1
UCEC	eIF4E →	+0.209	+2.115	.023	.019	3	1
UCEC	ACC1 →	+0.347	+2.820	.029	.035	3	1
UCEC	Ku80 →	+0.282	+1.884	.006	.030	3	1
UCEC	MEK1 →	+0.330	+3.321	.038	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Chk2_pT68 by SLC37A4 expression — UCEC

Explore this box plot interactively →