Across TCGA pan-cancer cohorts, SLC35G5 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SLC35G5’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC35G5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC35G5 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
HNSC, STAD, and CHOL are the cancer types where SLC35G5 tumor–normal differential expression is most reproducible.