Across TCGA pan-cancer cohorts, SLC35G4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SLC35G4’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where SLC35G4 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC35G4 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.
THCA and BRCA are the cancer types where SLC35G4 tumor–normal differential expression is most reproducible.