SLC35E4

Across TCGA patient cohorts, SLC35E4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC35E4-associated genes across cancer lineages are FoxM1, Rab11, and STAT3_pY705. Each is linked with SLC35E4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC35E4-to-partner and partner-to-SLC35E4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SLC35E4-low versus SLC35E4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC35E4→partner) and Y-score (partner→SLC35E4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.318	+2.817	.018	.036	3	1
UCEC	Rab11 →	-0.156	-3.321	.040	.010	3	1
UCEC	STAT3_pY705 →	-0.444	-3.321	.001	.010	3	1
UCEC	VHL →	-0.928	-3.000	.009	.036	3	1
UCEC	Caspase-8 →	-0.317	-3.321	.016	.010	3	1
UCEC	C-Raf →	+0.258	+3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FoxM1 by SLC35E4 expression — UCEC

Explore this box plot interactively →