SLC35E4

Across TCGA cell cohorts, SLC35E4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,727 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC35E4-associated GO terms across cancer lineages are Actin filament depolymerization, Negative regulation of small GTPase mediated signal transduction, and Positive regulation of stress fiber assembly. Each is linked with SLC35E4 in more than 12 cancer types. Because this analysis shows association rather than direction, both SLC35E4-to-partner and partner-to-SLC35E4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by SLC35E4-low versus SLC35E4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC35E4→partner) and Y-score (partner→SLC35E4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.222	+1.412	<.001	<.001	3	13
BONE	Negative regulation of small GTPase mediated signal transduction →	+0.073	+0.905	<.001	.001	3	13
BONE	Positive regulation of stress fiber assembly →	+0.136	+1.045	<.001	<.001	3	13
BONE	Positive regulation of actin filament bundle assembly →	+0.151	+0.976	<.001	<.001	3	12
SOFT_TISSUE	Keratinocyte development →	+0.429	+0.893	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Protein depolymerization →	+0.120	+1.528	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,727 associations by consensus.

Actin filament depolymerization by SLC35E4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →