SLC35E4

Across TCGA cell cohorts, SLC35E4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SLC35E4-associated genes across cancer lineages are USP17L3, SERPINA7, and OR4K1. Each is linked with SLC35E4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC35E4-to-partner and partner-to-SLC35E4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L3 grouped by SLC35E4-low versus SLC35E4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC35E4→partner) and Y-score (partner→SLC35E4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	USP17L3 →	+0.012	+4.922	.009	.009	3	1
LUNG_NSCLC_LUAD	SERPINA7 →	+0.006	+5.228	.005	.005	3	1
LUNG_NSCLC_LUAD	OR4K1 →	+0.019	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE2C →	+0.042	+5.662	<.001	.002	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

USP17L3 by SLC35E4 expression — BLOOD_Leukemia

Explore this box plot interactively →