SLC35E3

Across TCGA patient cohorts, SLC35E3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC35E3-associated genes across cancer lineages are PKC-delta_pS664, C-Raf, and Ku80. Each is linked with SLC35E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC35E3-to-partner and partner-to-SLC35E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by SLC35E3-low versus SLC35E3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC35E3→partner) and Y-score (partner→SLC35E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.182	-3.000	.008	.037	3	1
UCEC	C-Raf →	+0.242	+3.000	.003	.037	3	1
UCEC	Ku80 →	+0.310	+3.013	.023	.019	2	1
UCEC	Collagen-VI →	-0.234	-3.000	.049	.037	2	1
UCEC	ACC1 →	+0.444	+3.000	.034	.037	1	1
UCEC	PCNA →	+0.275	+3.000	.027	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PKC-delta_pS664 by SLC35E3 expression — UCEC

Explore this box plot interactively →