SLC35C2

Across TCGA patient cohorts, SLC35C2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC35C2-associated genes across cancer lineages are STAT3_pY705, FoxM1, and FOXO3a_pS318_S321. Each is linked with SLC35C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC35C2-to-partner and partner-to-SLC35C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SLC35C2-low versus SLC35C2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC35C2→partner) and Y-score (partner→SLC35C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.431	-3.311	<.001	.010	3	2
UCEC	FoxM1 →	+0.265	+1.884	.028	.030	3	1
UCEC	FOXO3a_pS318_S321 →	-0.152	-2.584	.008	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.195	-2.571	.013	.011	3	1
UCEC	JNK2 →	+0.391	+3.331	<.001	.005	3	1
UCEC	Ku80 →	+0.372	+3.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

STAT3_pY705 by SLC35C2 expression — UCEC

Explore this box plot interactively →