SLC35B3

Across TCGA patient cohorts, SLC35B3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC35B3-associated genes across cancer lineages are Annexin-1, EGFR_pY1068, and FOXO3a_pS318_S321. Each is linked with SLC35B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC35B3-to-partner and partner-to-SLC35B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by SLC35B3-low versus SLC35B3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC35B3→partner) and Y-score (partner→SLC35B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.623	+3.189	.008	.010	3	2
UCEC	EGFR_pY1068 →	-0.313	-3.169	.005	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.175	-3.321	.001	.009	3	1
UCEC	GAPDH →	+0.550	+2.999	.023	.035	3	1
UCEC	INPP4B →	-0.297	-2.321	.042	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.240	-3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Annexin-1 by SLC35B3 expression — UCEC

Explore this box plot interactively →