SLC35B3

Across TCGA cell cohorts, SLC35B3 mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC35B3-associated genes across cancer lineages are Fulvestrant, WYE-125132, and PRT062607. Each is linked with SLC35B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC35B3-to-partner and partner-to-SLC35B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fulvestrant grouped by SLC35B3-low versus SLC35B3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC35B3→partner) and Y-score (partner→SLC35B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Fulvestrant →	+0.461	+2.649	.006	.046	3	1
LARGE_INTESTINE	WYE-125132 →	+0.617	+2.652	.015	.045	3	1
LARGE_INTESTINE	PRT062607 →	+0.522	+2.769	.039	.040	2	1
LARGE_INTESTINE	AZD5991 →	+1.020	+2.649	.006	.046	2	1
LARGE_INTESTINE	729189 →	+0.287	+2.649	.024	.046	2	1
LARGE_INTESTINE	ZSTK474 →	+0.556	+2.786	.034	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Fulvestrant by SLC35B3 expression — LARGE_INTESTINE

Explore this box plot interactively →