SLC35A3

Across TCGA patient cohorts, SLC35A3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC35A3-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and GAPDH. Each is linked with SLC35A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC35A3-to-partner and partner-to-SLC35A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SLC35A3-low versus SLC35A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC35A3→partner) and Y-score (partner→SLC35A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.101	-3.295	.021	.009	3	1
UCEC	EGFR_pY1068 →	-0.263	-2.321	.016	.034	3	1
UCEC	GAPDH →	+0.463	+2.321	.048	.034	3	1
UCEC	GATA6 →	-0.190	-2.985	.006	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-2.321	.006	.034	3	1
UCEC	JNK2 →	+0.302	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by SLC35A3 expression — UCEC

Explore this box plot interactively →