Across TCGA pan-cancer cohorts, SLC34A3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SLC34A3 data layer compared with 3 for mutation status and 5 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC34A3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SLC34A3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.
HNSC, ACC, and COAD are the cancer types where SLC34A3 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.