Across TCGA pan-cancer cohorts, SLC34A3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC34A3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SLC34A3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC34A3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, GBM, and PDAC are the cancer types where SLC34A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.520	0.905	.003	21	view →
GBM	DFS	Median	All	0.248	0.475	.009	10	view →
PDAC	DFS	Quartile	III,IV	0.234	0.904	.006	8	view →
CCRCC	OS	Median	All	1.000	0.900	.022	6	view →
LUAD	DFS	Median	III,IV	0.925	0.413	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SLC34A3 tumor-vs-normal RNA expression · all SLC34A3 data types